6-Chloropurine and 6-Chlorouric Acid as Substrates and Inhibitors of Purine-oxidizing Enzymes
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منابع مشابه
6-Chloropurine and 6-chlorouric acid as substrates and inhibitors of purine-oxidizing enzymes.
Various examples of oxidation of purine molecules in positions 8 and 2 by xanthine oxidase have been reported. The conversions of the natural purine substrates, xanthine and hypoxanthine to uric acid (I) and of adenine to 2,8-dihydroxy-6-aminopurine, are well known. The oxidation of the purine antimetabolites, 6-mercaptopurine to 6-thiouric acid (2)) 2,6-diaminopurine to 2,6-diamino-6-hydroxy p...
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A atividade antitireóidea do 6-cloropurina, in vitro, foi determinada espectrofotometricamente por estudos de formação de seu complexo com iodo. O complexo mostrou estequiometria de 1:1. A constante de formação do complexo encontrada foi 7,652 × 10 L mol, o que indicou um bom potencial de 6-cloropurina, como agente antitireóideo. Posteriores verificações mostraram mudanças nos níveis hormonais ...
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6-Chloropurine and 6-chlorouric acid effect specific inhibitions of xanthine oxidase and uricase, respectively, in both slices and homogenates of rat liver. In the rat in vivo, a similarly potent inhibition of uricase is achieved by 6-chlorouric acid, whether administered as such or formed in vivo by the oxidation of 6-chloropurine. 6-Chloropurine in vivo and in liver slices effects only a slig...
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Simultaneous administration of 6-chloropurine and azaserine in the therapy of mice bearing the ascites cell forms of Sarcoma 180 or the Ehrlich carcinoma resulted in a potentiation of tumor inhibition as measured by increases in survival time. The 6C3HED and the Mecca ascites lymphosarcomas proved resistant to the combination of chloropurine and azaserine employed. Hepatoma 134 was sensitive to...
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Objective(s): In the present study,a new series of 6-methoxy-2-arylquinoline analogues was designed and synthesized as P-glycoprotein (P-gp) inhibitors using quinine and flavones as the lead compounds. Materials and Methods: The cytotoxic activity of the synthesized compounds was evaluated against two human cancer cell lines including EPG85-257RDB, multidrug-resistant gastric carcinoma cells (P...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1959
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)69873-4